Downloadlinks

• Information about the Dutch book about immune psychiatrie
• Newsitem in Dutch, 20 / 03 / 2019, Gerben Stolk on www.amazingerasmus.nl: Bron stemmingsstoornis beter in beeld.
• Publishable Summary first period MOODSTRATIFICATION, august 2019.
• Publishable Summary second period MOODSTRATIFICATION, july 2021.
• Publishable Summary third period MOODSTRATIFICATION, april 2023

 

Scientific publications 2017 – 2023

The following scientific publications are based on data of MOODSTRATIFICATION, MOODINFLAME and/or PSYCH-AID:  

2023

Since focus was the last year clearly on the execution of the various immune intervention trials (DEPIL, IL2REG and MOODSTRATA) and the collection of materials and data in these trials, and since we only have the outcome of these trials in M63- M66 we have been unable to present these data on conferences and meetings. We will do so in the coming two years, but presently the list of publications is thus limited for the last year.

 

                             Publications

Simon MS, Schiweck C, Arteaga-Henriquez G, et al. Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression. Prog Neuropsychopharmacol Bio 111:l Psychiatry. 2021;110391. Doi:10.1016/j.pnpb.2021.110391.

Simon MS, Ioannou M, Arteaga-Henriquez G, et al, Premature T-cell aging in major Depression: a double hit by the state of disease and cytomegalovirus infection. Brain Behav Immun Health. 2023; 29:100608. Doi:10.1016/j.bbih.2023.100609

Scheiber C, Dulovic A, Bechter K and Schneider EM. Plasma autoantibodies in patients with Affective and Schizophrenic Spectrum Disorders. Journal of Affective Disorders Reports, Volume12,m supplement, 2023, 100563, ISSN 2666-9153 http:// doi.org/10.1016/j.jadr.2023.100563 

Schneider EM, Schneider JM, Scheiber C, Li C, Fohr K, Steinacker JM and Bechter K. Inflammatory macrophages in patients with fatigue. Journal of Affective Disorders Reports, Volume 12, Supplement, 2023, 100564, ISSN 2666-9153 Htpps://doi.org/10.1016/j.jadr.2023.100564

Drexhage H.A. The state of the art in het EU Horizon 2020 project Moodstratification.  Journal of Affective Disorders Reports, Volume 12 Supplement 2023, 100537 http;//doi.orgt10.1016/j/jadr.2023.100537

Whinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, Hajek T; ENIGMA Bipolar Disorders Working Group. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. Bipolar Disord. 2022 Aug;24(5):509-520. doi: 10.1111/bdi.13172. Epub 2021 Dec 16. PMID: 34894200; PMCID: PMC9187778.

McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze LMF, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Jahanshad N, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, Hajek T; ENIGMA Bipolar Disorder Working Group. Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants. Psychol Med. 2023 Feb 27:1-11. doi: 10.1017/S0033291723000223. Epub ahead of print. PMID: 36846964.

Grandjean EL, van Zonneveld SM, Sommer IEC, Haarman BCM. Anti-inflammatory dietary patterns to treat bipolar disorder? J Affect Disord. 2022 Aug 15;311:254-255. doi: 10.1016/j.jad.2022.05.073. Epub 2022 May 19. PMID: 35598750.

Anmella G, Faurholt-Jepsen M, Hidalgo-Mazzei D, Radua J, Passos IC, Kapczinski F, Minuzzi L, Alda M, Meier S, Hajek T, Ballester P, Birmaher B, Hafeman D, Goldstein T, Brietzke E, Duffy A, Haarman B, López-Jaramillo C, Yatham LN, Lam RW, Isometsa E, Mansur R, McIntyre RS, Mwangi B, Vieta E, Kessing LV. Smartphone-based interventions in bipolar disorder: Systematic review and meta-analyses of efficacy. A position paper from the International Society for Bipolar Disorders (ISBD) Big Data Task Force. Bipolar Disord. 2022 Sep;24(6):580-614. doi: 10.1111/bdi.13243. Epub 2022 Aug 11. PMID: 35839276; PMCID: PMC9804696.

Lavin P, Rej S, Olagunju AT, Teixeira AL, Dols A, Alda M, Almeida OP, Altinbas K, Balanzá-Martínez V, Barbosa IG, Blumberg HP, Briggs F, Calkin C, Cassidy K, Forester BP, Forlenza OV, Hajek T, Haarman BCM, Jimenez E, Lafer B, Mulsant B, Oluwaniyi SO, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares JC, Tsai SY, Vieta E, Villa LM, Sajatovic M, Eyler LT. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE-BD group. Bipolar Disord. 2023 Feb 26. doi: 10.1111/bdi.13312. Epub ahead of print. PMID: 36843436.

Manusama O, Singh S, Brooimans RA, Wijkhuijs A, van der Ent M, Drexhage HA, Dalm VA. Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment? Int Immunopharmacol. 2023 Jun;119:110168. doi: 10.1016/j.intimp.2023.110168. Epub 2023 Apr 20

Tomasik J, Schiweck C, Drexhage HA. A Sticky Situation: The Link Between Peripheral Inflammation, Neuroinflammation, and Severe Mental Illness. Biol Psychiatry. 2023 Jan 15;93(2):107-109. doi: 10.1016/j.biopsych.2022.10.017.

Aichholzer M, Gangadin SS, Sommer IEC, Wijkhuis A, de Witte LD, Kahn RS, Bahn S, Drexhage   HA, Schiweck C. Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial. Brain Behav Immun Health. 2022 Nov 8;26:100551. doi: 10.1016/j.bbih.2022.100551. eCollection 2022

Moss CS, Drexhage HA and Rutten S. Wederkerige interacties tussen chronische stress en het neuro-endocriene en immuun systeem. In: Het lichaam en psychisch functioneren. Theorie, onderzoek en klinische toepassing (Redactie: Eurelings EHM, Kooiman CG, Lub MH), pp 29-72. Bohn, Stafleu, van Loghum, Houten 2022

 

                             Abstracts 

Conference abstracts

Scheiber C, Dulovic A, Bechter K and Schneider EM. Plasma autoantibodies in patients with Affective and Schizophrenic Spectrum Disorders. Journal of Affective Disorders Reports, Volume 12, Supplement, 2023, 100563, ISSN 2666-9153. https://doi.org/10.1016/j.jadr.2023.100563. 16^th Psychoimmunology Expert Meeting April 2, 2023 (Günzburg)

Schneider EM, Schneider JM, Scheiber C, Li C, Föhr K, Steinacker JM and Bechter K. Inflammatory macrophages in patients with fatigue. Journal of Affective Disorders Reports, Volume 12, Supplement, 2023, 100564, ISSN   2666-9153.   https://doi.org/10.1016/j.jadr.2023.100564. 16^th Psychoimmunology Expert Meeting April 2, 2023 (Günzburg).

Marion Schneider. Flow Cytometric analysis of autoimmune phenotypes. Conference on „New trends in molecular and immunological detection methodology of persistent viral infections”, Riga Stradins University Summerschool 2022 (11-15 July 2022).

Marion Schneider, Kunal Garg. Autoantibody profiles against Interferons and cytokines in patients with depression, virus infections, CFS-ME and MDD. Conference on „New trends in molecular and immunological detection methodology of persistent viral infections”, Riga Stradins University Summerschool 2022 (11-15 July 2022).

 Palladini et al. Inflammatory signature of post-COVID-19 depression. EPA congres 2023

Palladini et al. Putative inflammatory signature of post-COVID-19 depression: a longitudinal study ECNP congres 2023

 Colombo et al. Immune-inflammation and structural neuroimaging differentiate bipolar and unipolar depression: a machine learning study. ECNP congres 2022

Raffaelli et al. Predicting unipolar and bipolar depression using inflammatory markers, neuroimaging and neuropsychological data: a machine learning study. EPA congres 2023

Bravi et al. Choroid plexus volume as a proxy of neuroinflammation in depression. EPA congres 2023

Paolini et al. Effect of Neutrophil to Lymphocyte ratio on antidepressant treatment response: moderating effect of sex and mediating effect of Hippocampal volumes. EPA congres 2023

 

Conference presentations

Scheiber C, Klein HC, Bechter K and Schneider EM. HSV-1 specific miRNAs in cerebrospinal fluid. 17^th ROSTOCK SYMPOSION for Tumor Immunology and Brain Tumor Research in Pediatrics February 3, 2023 (Rostock).

Bechter K. What do the frequent CSF abnormalities in severe mental disorders mean? 16th Psychoimmunology Expert Meeting April 2, 2023 (Günzburg)

Schneider, E. M. The immunological phenotype, molecular and genetic predisposition in post-/ long-COVID and MDD patients. Sporte Medicine and Health Summit, Hamburg June 24-26, 2023.

 Organization of Scientific Meeting + Editor of Special Issue of Journal of Affective Disorders Reports, in press

Bechter K. Main organizer of 16^th Psychoimmunology Expert Meeting April 2, 2023 (Günzburg), program at www.psychoimmunology-experts.de and in Special Issue of Journal of Affective disorders Reports , in press

2022

Comai S, Melloni E, Lorenzi C, Bollettini I, Vai B, Zanardi R, Colombo C, Valtorta F, Benedetti F, Poletti S (2022). Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression. In: Eur Neuropsychopharmacol. 2022 Feb;55:96-109. doi: 10.1016/j.euroneuro.2021.11.003. Epub 2021 Nov 27.

Gronemann, F.H., Lund, T., Lindholdt, L. et al. Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study. Soc Psychiatry Psychiatr Epidemiol 57, 1189–1199 (2022). https://doi.org/10.1007/s00127-022-02243-9 

Manusama OR, van Beveren NJM, van Hagen PM, Drexhage HA, Dalm VASH (2022). Psychological Symptoms in Primary Immunodeficiencies: a Common Comorbidity?
In: Journal of Clinical Immunology. https://doi.org/10.1007/s10875-022-01207-7

Scheiber C, Schulz T, Schneider JM, Bechter K, Schneider EM (2022). Old and New Biomarkers for Infection, Inflammation, and Autoimmunity in Treatment-Resistant Affective and Schizophrenic Spectrum Disorders. Pharmaceuticals (Basel). 2022 Feb 28;15(3):299. doi: 10.3390/ph15030299. PMID: 35337097; PMCID: PMC8949012

2021

Serra I, Manusama OR, Fabian M.P. Kaiser FMP, Floriano II e.a (2021). Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model – ScienceDirect/ In: Brain, Behavior, & Immunity – Health 18 (2021). Open access in ScienceDirect. Article 100377.

Madsen KB, Momen NC, Petersen LV, Plana-Ripoll O, Haarman BCM, Drexhage H, Mortensen PB, McGrath JJ, Munk-Olsen T. (2021) Bidirectional associations between treatment-resistant depression and general medical conditions. Eur Neuropsychopharmacol. 2021 Oct;51:7-19.
doi: 10.1016/j.euroneuro.2021.04.021. Epub 2021 May 21. PMID: 34023798.

Ioannou M, Foiselle M, Mallet J, Stam EL, Godin O, Dubertret C, Terro E, Sommer IEC, Haarman BCM, Leboyer M, Schoevers RA. (2021) Towards precision medicine: What are the stratification hypotheses to identify homogeneous inflammatory subgroups. Eur Neuropsychopharmacol. 2021 Apr;45:108-121. doi:10.1016/j.euroneuro.2020.11.001. Epub 2020 Nov 12. PMID: 33189523.

Benedetti F, Poletti S, Vai B, Mazza GM, Lorenzi C, Brioschi S, Aggio V, Branchi I, Colombo C, Furlan R, Zanardi R (2021). Higher baseline interleukin-1β and TNF-α hamper antidepressant response in major depressive disorder. Eur Neuropsychopharmacol . 2021 Jan;42:35-44. doi: 10.1016/j.euroneuro.2020.11.009. Epub 2020 Nov 13. PMID: 33191075. 

Poletti S, Mazza MG, Calesella F, Vai B, Lorenzi C, Manfredi E, Colombo C, Zanardi R, Benedetti F (2021). Circulating inflammatory markers impact cognitive functions in bipolar depression. In: J Psychiatr Res . 2021 Aug;140:110-116. doi: 10.1016/j.jpsychires.2021.05.071. Epub 2021 Jun 2

Arteaga-Henriquez G, Burger B, Weidinger E, Grosse L, Moll N, Schuetze G, Schwarz M, Wijkhuijs A, Op de Beeck G, Berghmans R, Versnel MA, Arolt V, Müller N, Drexhage HA (2021).
Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: A link to the monocyte inflammatory state of patients.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 20;107:110226. doi: 10.1016/j.pnpbp.2020.110226. Epub 2020 Dec 18.PMID: 33346015 Free article.

Branchi I, Poggini S, Capuron L, Benedetti F, Poletti S, Tamouza R, Drexhage HA, Penninx BWJH, Pariante CM; European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group and Marion Leboyer (2021).
Brain-immune crosstalk in the treatment of major depressive disorder.
Eur Neuropsychopharmacol. 2021 Apr;45:89-107. doi: 10.1016/j.euroneuro.2020.11.016. Epub 2020 Dec 29.PMID: 33386229

Simon MS, Burger B, Weidinger E, Arteaga-Henríquez G, Zill P, Musil R, Drexhage HA, Müller N (2021).
Efficacy of Sertraline Plus Placebo or Add-On Celecoxib in Major Depressive Disorder: Macrophage Migration Inhibitory Factor as a Promising Biomarker for Remission After Sertraline-Results From a Randomized Controlled Clinical Trial.
Front Psychiatry. 2021 Sep 27;12:615261. doi: 10.3389/fpsyt.2021.615261. eCollection 2021.PMID: 34646168 Free PMC article.

Simon MS, Schiweck C, Arteaga-Henríquez G, Poletti S, Haarman BCM, Dik WA, Schwarz M, Vrieze E, Mikova O, Joergens S, Musil R, Claes S, Baune BT, Leboyer M, Benedetti F, Furlan R, Berghmans R, de Wit H, Wijkhuijs A, Arolt V, Müller N, Drexhage HA (2021).
Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression. 
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110391. doi: 10.1016/j.pnpbp.2021.110391. Epub 2021 Jun23.PMID: 34171401 Free article.

2020

Bang Madsen, K., Vogdrup Petersen, L., Plana-Ripoll, O., Musliner, K. L., Philippe Debost, J-C., Hordam Gronemann, F., Mortensen, P. B. & Munk-Olsen, T (2020).
Early labor force exits in patients with treatment-resistant depression: an assessment of work years lost in a Danish nationwide register-based cohort study.
In: Therapeutic advances in psychopharmacology, 2020 Nov 17; 10:2045125320973791. doi: 10.1177/2045125320973791. eCollection 2020. PMID: 33282176 Free PMC article.

Madsen, K. B., Plana-Ripoll, O., Musliner, K. L., Debost, J-C. P., Petersen, L. V. & Munk-Olsen, T (2020).
Cause-specific life years lost in individuals with treatment-resistant depression: A Danish nationwide register-based cohort study.
In: Journal of Affective Disorders. 280, Pt A, s. 250-257. doi: 10.1016/j.jad.2020.11.042. Online ahead of print.PMID: 33220561.

Osborne LM, Gilden J, Kamperman AM, Hoogendijk WJG, Spicer J, Drexhage HA, Bergink V (2020).
T-cell defects and postpartum depression. 
Brain Behav Immun. 2020 Jul;87:397-403. doi: 10.1016/j.bbi.2020.01.007. Epub 2020 Jan 8.PMID: 31926288.

Poletti S, Mazza MG, Vai B, Lorenzi C, Colombo C, Benedetti (2020)
Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder.
Front Psychiatry. 2020 Dec 8;11:590095. doi: 10.3389/fpsyt.2020.590095. eCollection 2020.

Pollak TA, Lennox BR, Müller S, Benros ME, Prüss H, Tebartz van Elst L, Klein H, Steiner J, Frodl T, Bogerts B, Tian L, Groc L, Hasan A, Baune BT, Endres D, Haroon E, Yolken R, Benedetti F, Halaris A, Meyer JH, Stassen H, Leboyer M, Fuchs D, Otto M, Brown DA, Vincent A, Najjar S, Bechter K (2020).
Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. 
Lancet Psychiatry. 2020 Jan;7(1):93-108. doi: 10.1016/S2215-0366(19)30290-1. Epub 2019 Oct 24.PMID: 31669058 Review.

Schiweck C, Claes S, Van Oudenhove L, Lafit G, Vaessen T, de Beeck GO, Berghmans R, Wijkhuijs A, Müller N, Arolt V, Drexhage H, Vrieze E (2020).
Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression.
Transl Psychiatry. 2020 Aug 24;10(1):296. doi: 10.1038/s41398-020-00979-z.PMID: 32839428. Free PMC article.

Schiweck C, Valles-Colomer M, Arolt V, Müller N, Raes J, Wijkhuijs A, Claes S, Drexhage H, Vrieze E (2020).
Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells.
Brain Behav Immun. 2020 Jul;87:603-609. doi: 10.1016/j.bbi.2020.02.005. Epub 2020 Feb 14.PMID: 32061905.

Schiweck, C. (2020). Paving the road for precision medicine: the role of stress monitoring and inflammation in depression. Thesis KU Leuven, source ID: LIRIAS2957669.

2019

Arteaga-Henríquez G, Simon MS, Burger B, Weidinger E, Wijkhuijs A, Arolt V, Birkenhager TK, Musil R, Müller N, Drexhage HA (2019).
Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium. 
Front Psychiatry. 2019 Jul 9;10:458. doi: 10.3389/fpsyt.2019.00458. eCollection 2019.

Drexhage HA (2019).
Editorial: Activation and de-activation of inflammatory pathways. The disequilibrium of immune-neuro-endocrine networks in psychiatric disorders.
Brain Behav Immun. 2019 Jan 22. pii: S0889-1591(19)30051-0. doi: 10.1016/j.bbi.2019.01.007. [Epub ahead of print].

Müller N, Krause D, Barth R, Myint AM, Weidinger E, Stettinger W, Zill P, Drexhage HA, Schwarz MJ (2019).
Childhood Adversity and Current Stress are related to Pro- and Anti-inflammatory Cytokines in Major Depression.
J Affect Disord. 2019 Apr 22;253:270-276. doi: 10.1016/j.jad.2019.04.088. [Epub ahead of print]

Poletti S, Leone G, Hoogenboezem TA, Ghiglino D, Vai B, de Wit H, Wijkhuijs AJM, Locatelli C, Colombo C, Drexhage HA, Benedetti F. (2019)
Markers of neuroinflammation influence measures of cortical thickness in bipolar depression.
Psychiatry Res Neuroimaging. 2019 Mar 30;285:64-66. doi: 10.1016/j.pscychresns.2019.01.009. Epub 2019 Jan 29.

Snijders G, Brouwer R, Kemner S, Bootsman F, Drexhage HA, Hillegers MHJ (2019).
Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder.
Int J Bipolar Disord. 2019 Feb 10;7(1):4. doi: 10.1186/s40345-018-0139-3.

2018

Becking K, Haarman BCM, Grosse L, Nolen WA, Claes S, Arolt V, Schoevers RA, Drexhage HA (2018).
The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder.
J Neuroimmunol. 2018 Jun 15;319:28-36. doi: 10.1016/j.jneuroim.2018.03.004. Epub 2018 Mar 21.

Counotte J, Drexhage HA, Wijkhuijs JM, Pot-Kolder R, Bergink V, Hoek HW, Veling W (2018).
Th17/T regulator cell balance and NK cell numbers in relation to psychosis liability and social stress reactivity.
Brain Behav Immun. 2018 Mar;69:408-417.

Haarman BCM, Burger H, Drexhage HA, Nolen WA, Riemersma-Van der Lek RF (2018).
The dysregulated brain – Consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis.
Tijdschr Psychiatr. 2018;60(2):105-113.