Scientific publications 2017 – 2020

The following scientific publications in this period are based on the data of MOODSTRATIFICATION, MOODINFLAME and/or PSYCH-AID:  


Poletti S, Mazza MG, Vai B, Lorenzi C, Colombo C, Benedetti Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder. Front Psychiatry. 2020 Dec 8;11:590095. doi: 10.3389/fpsyt.2020.590095. eCollection 2020.

Madsen, K. B., Plana-Ripoll, O., Musliner, K. L., Debost, J-C. P., Petersen, L. V. & Munk-Olsen, T. (2020) Cause-specific life years lost in individuals with treatment-resistant depression: A Danish nationwide register-based cohort study. 10 nov. 2020, In: Journal of Affective Disorders. 280, Pt A, s. 250-257. doi: 10.1016/j.jad.2020.11.042. Online ahead of print.PMID: 33220561

Bang Madsen, K., Vogdrup Petersen, L., Plana-Ripoll, O., Musliner, K. L., Philippe Debost, J-C., Hordam Gronemann, F., Mortensen, P. B. & Munk-Olsen, T. (2020) Early labor force exits in patients with treatment-resistant depression: an assessment of work years lost in a Danish nationwide register-based cohort study. In: Therapeutic advances in psychopharmacology, 2020 Nov 17; 10:2045125320973791. doi: 10.1177/2045125320973791. eCollection 2020. PMID: 33282176 Free PMC article.

Schiweck C, Claes S, Van Oudenhove L, Lafit G, Vaessen T, de Beeck GO, Berghmans R, Wijkhuijs A, Müller N, Arolt V, Drexhage H, Vrieze E (2020). Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression. Transl Psychiatry. 2020 Aug 24;10(1):296. doi: 10.1038/s41398-020-00979-z.PMID: 32839428Free PMC article.

Schiweck C, Valles-Colomer M, Arolt V, Müller N, Raes J, Wijkhuijs A, Claes S, Drexhage H, Vrieze E (2020). Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells. Brain Behav Immun. 2020 Jul;87:603-609. doi: 10.1016/j.bbi.2020.02.005. Epub 2020 Feb 14.PMID: 32061905

Osborne LM, Gilden J, Kamperman AM, Hoogendijk WJG, Spicer J, Drexhage HA, Bergink V (2020). T-cell defects and postpartum depression. Brain Behav Immun. 2020 Jul;87:397-403. doi: 10.1016/j.bbi.2020.01.007. Epub 2020 Jan 8.PMID: 31926288.

Pollak TA, Lennox BR, Müller S, Benros ME, Prüss H, Tebartz van Elst L, Klein H, Steiner J, Frodl T, Bogerts B, Tian L, Groc L, Hasan A, Baune BT, Endres D, Haroon E, Yolken R, Benedetti F, Halaris A, Meyer JH, Stassen H, Leboyer M, Fuchs D, Otto M, Brown DA, Vincent A, Najjar S, Bechter K. (2020) Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. Lancet Psychiatry. 2020 Jan;7(1):93-108. doi: 10.1016/S2215-0366(19)30290-1. Epub 2019 Oct 24.PMID: 31669058 Review.


Arteaga-Henríquez G, Simon MS, Burger B, Weidinger E, Wijkhuijs A, Arolt V, Birkenhager TK, Musil R, Müller N, Drexhage HA. Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium. Front Psychiatry. 2019 Jul 9;10:458. doi: 10.3389/fpsyt.2019.00458. eCollection 2019

Müller N, Krause D, Barth R, Myint AM, Weidinger E, Stettinger W, Zill P, Drexhage HA, Schwarz MJ. (2019)
Childhood Adversity and Current Stress are related to Pro- and Anti-inflammatory Cytokines in Major Depression.
J Affect Disord. 2019 Apr 22;253:270-276. doi: 10.1016/j.jad.2019.04.088. [Epub ahead of print]

Poletti S, Leone G, Hoogenboezem TA, Ghiglino D, Vai B, de Wit H, Wijkhuijs AJM, Locatelli C, Colombo C, Drexhage HA, Benedetti F. (2019)
Markers of neuroinflammation influence measures of cortical thickness in bipolar depression.
Psychiatry Res Neuroimaging. 2019 Mar 30;285:64-66. doi: 10.1016/j.pscychresns.2019.01.009. Epub 2019 Jan 29.

Snijders G, Brouwer R, Kemner S, Bootsman F, Drexhage HA, Hillegers MHJ (2019).
Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder.
Int J Bipolar Disord. 2019 Feb 10;7(1):4. doi: 10.1186/s40345-018-0139-3.

Drexhage HA (2019).
Editorial: Activation and de-activation of inflammatory pathways. The disequilibrium of immune-neuro-endocrine networks in psychiatric disorders.
Brain Behav Immun. 2019 Jan 22. pii: S0889-1591(19)30051-0. doi: 10.1016/j.bbi.2019.01.007. [Epub ahead of print].


Becking K, Haarman BCM, Grosse L, Nolen WA, Claes S, Arolt V, Schoevers RA, Drexhage HA (2018).
The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder.
J Neuroimmunol. 2018 Jun 15;319:28-36. doi: 10.1016/j.jneuroim.2018.03.004. Epub 2018 Mar 21.

Haarman BCM, Burger H, Drexhage HA, Nolen WA, Riemersma-Van der Lek RF (2018).
The dysregulated brain – Consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis.
Tijdschr Psychiatr. 2018;60(2):105-113.

Counotte J, Drexhage HA, Wijkhuijs JM, Pot-Kolder R, Bergink V, Hoek HW, Veling W (2018).
Th17/T regulator cell balance and NK cell numbers in relation to psychosis liability and social stress reactivity.
Brain Behav Immun. 2018 Mar;69:408-417.


Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, Colombo C, Drexhage HA (2017).
Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder. 
J Clin Psychiatry. 2017 Sep/Oct;78(8):e986-e993.

Snijders G, Mesman E, de Wit H, Wijkhuijs A, Nolen WA, Drexhage HA, Hillegers MHJ (2017).
Immune dysregulation in offspring of a bipolar parent. Altered serum levels of immune growth factors at adolescent age.
Brain Behav Immun. 2017 Aug;64:116-123.

Vogels RJ, Koenders MA, van Rossum EF, Spijker AT, Drexhage HA (2017).
T Cell Deficits and Overexpression of Hepatocyte Growth Factor in Anti-inflammatory Circulating Monocytes of Middle-Aged Patients with Bipolar Disorder Characterized by a High Prevalence of the Metabolic Syndrome. 
Front Psychiatry. 2017;8:34.

Snijders G, de Witte L, Mesman E, Kemner S, Vonk R, Brouwer R, Nolen WA, Drexhage HA, Hillegers MHJ (2017).
The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies. 
Int J Bipolar Disord. 2017 Dec;5(1):1.

Poletti S, de Wit H, Mazza E, Wijkhuijs AJM, Locatelli C, Aggio V, Colombo C, Benedetti F, Drexhage HA (2017).
Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls. 
Brain Behav Immun. 2017 Mar;61:317-325.

Poletti S, Aggio V, Hoogenboezem TA, Ambrée O, de Wit H, Wijkhuijs AJ, Locatelli C, Colombo C, Arolt V, Drexhage HA, Benedetti F (2017).
Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder. 
Eur Psychiatry. 2017 Feb;40:33-37.

Maria NI, Steenwijk EC, IJpma AS, van Helden-Meeuwsen CG, Vogelsang P, Beumer W, Brkic Z, van Daele PL, van Hagen PM, van der Spek PJ, Drexhage HA, Versnel MA (2017).
Contrasting expression pattern of RNA-sensing receptors TLR7, RIG-I and MDA5 in interferon-positive and interferon-negative patients with primary Sjögren’s syndrome. 
Ann Rheum Dis. 2017 04;76(4):721-730.